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Article Details


Progranulin Regulates Inflammation and Tumor

[ Vol. 19 , Issue. 2 ]

Author(s):

Chunxiao Liu, Jiayi Li, Wenjing Shi, Liujia Zhang, Shuang Liu, Yingcong Lian, Shujuan Liang and Hongyan Wang*   Pages 88 - 102 ( 15 )

Abstract:


Progranulin (PGRN) mediates cell cycle progression and cell motility as a pleiotropic growth factor and acts as a universal regulator of cell growth, migration and transformation, cell cycle, wound healing, tumorigenesis, and cytotoxic drug resistance as a secreted glycoprotein. PGRN overexpression can induce the secretion of many inflammatory cytokines, such as IL-8, -6,-10, TNF-α. At the same time, this protein can promote tumor proliferation and the occurrence and development of many related diseases such as gastric cancer, breast cancer, cervical cancer, colorectal cancer, renal injury, neurodegeneration, neuroinflammatory, human atherosclerotic plaque, hepatocarcinoma, acute kidney injury, amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson’s disease. In short, PGRN plays a very critical role in injury repair and tumorigenesis, it provides a new direction for succeeding research and serves as a target for clinical diagnosis and treatment, thus warranting further investigation. Here, we discuss the potential therapeutic utility and the effect of PGRN on the relationship between inflammation and cancer.

Keywords:

Cell cycle, cell motility, inflammation, pleiotropic growth factor, progranulin, tumor.

Affiliation:

Pathogenic Microbiology, Clinical Medical College, Weifang Medical University, Shandong 261053, Pathogenic Microbiology, Clinical Medical College, Weifang Medical University, Shandong 261053, Department of Gynecology, Weifang Medical University Affiliated Hospital, Weifang, Shandong 261031, Clinical Medical College, Weifang Medical University, Shandong 261053, Clinical Medical College, Weifang Medical University, Shandong 261053l College, Weifang Medical University, Shandong 261053, Clinical Medical College, Weifang Medical University, Shandong 261053, Key Lab for Immunology in Universities of Shandong Province, Clinical Medical College, Weifang Medical University, Shandong 261053, Pathogenic Microbiology, Clinical Medical College, Weifang Medical University, Shandong 261053



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