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New Anti-inflammatory Triterpene Esters and Glycosides from Alstonia scholaris

[ Vol. 19 , Issue. 4 ]


Nighat Sultana*, Muhammad Saleem Qazi and Mustafa Kamal   Pages 370 - 386 ( 17 )


Background: Phytochemical studies on the ethanolic extract of aerial parts of Alstonia scholaris lead to the isolation of two new triterpenoid of the lanostanetype, lanosta 5ene,24-ethyl-3-O-β-D-glucopyranoside (1), lanosta,5ene,24-ethyl-3-O-β-D-glucopyranosideester (2) and new ursane type triterpenoidmethylester, 12-ursene-2,3,18,19-tetrol,28 acetate (nighascholarene) (3), together with seven known triterpenes, betuline, triterpene of the lupane type, alstoprenyol (4), 3β-hydroxy-28-β-acetoxy-5-olea triterpene (5),α-amyrin acetate (6), α-amyrin (7), lupeol acetate (8), 3β-hydroxy-24-nor-urs-4,12,28-triene triterpene (9) and ursolic acid (l0).

Methodology: The triterpenoid structures of these colorless compounds were deduced from the 1H and 13C-NMR data, and in particular from the application of two-dimensional 1H, 13C correlation experiments as well as by comparison with reported literature data.

Results and Conclusion: This study deals with isolation and structural elucidation of natural new triterpenoidesters and glycosides with anti-inflammatory activity.


Alstonia scholaris, apocynaceae, spectroscopicstudies, triterpene, triterpenoidester, glycosides.


Pharmaceutical Research Center, PCSIR Laboratories Complex, Karachi, Department of Biotechnology, University of Karachi, Karachi, Department of Biotechnology, University of Karachi, Karachi

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