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Psoralen Derivatives: Recent Advances of Synthetic Strategy and Pharmacological Properties

Author(s):

Joazaizulfazli Jamalis*, Faten Syahira Mohamed Yusof, Subhash Chander, Roswanira Abd Wahab, Deepak P. Bhagwat, Murugesan Sankaranarayanan, Faisal Almalki and Taibi Ben Hadda   Pages 1 - 18 ( 18 )

Abstract:


Introduction: Psoralen or furocoumarin is a linear three ring heterocyclic compound. Psoralens are planar, tricyclic compounds, consisting of a furan ring fused to a coumarin moiety. Psoralen has been known for a wide spectrum of biological activities, spanning from cytotoxic, photosensitizing, insecticidal, antibacterial to antifungal effect. Thus, several structural changes were introduced to explore the role of specific positions with respect to the biological activity. Convenient approaches utilized for the synthesis of psoralen skeleton can be categorized into two parts:

(i) The preparation of the tricyclic ring system from resorcinol.

(ii)The exocyclic modification of the intact ring system.

Conclusion: Furthermore, although psoralens have been used in diverse ways, we mainly focus in this work on their clinical utility for the treatment of psioraisis, vitiligo and skin-related disorder.

Keywords:

Psoralen, heterocyclic, synthesis, pharmacological, organic

Affiliation:

Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103. Himachal Pradesh, Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Johor Bahru, Johor, School of Pharmacy, Maharaja Agrasen University, Atal Shiksha Kunj, Village Kalujhanda, Solan-174103. Himachal Pradesh, Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology & Science Pilani, Pilani Campus, Pilani-333031. Rajasthan, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah Almukkarramah, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah Almukkarramah



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