Submit Manuscript  

Article Details


Analgesic and Anti-inflammatory Effects of Caryocar brasiliense

[ Vol. 19 , Issue. 3 ]

Author(s):

Armando Jorge Junior, Maicon Matos Leitão, Laura Priscila Toledo Bernal, Elisângela dos Santos, Ângela Midori Kuraoka-Oliveira, Priscila Justi, Eliana Janet Sanjinez Argandoña and Cândida Aparecida Leite Kassuya*   Pages 313 - 322 ( 10 )

Abstract:


Background: Caryocar brasiliense, popularly known as pequi, is widely distributed in the Amazon rainforest and Brazilian savannah. The fruit obtained from pequi is used in cooking and has folk use as an anti-inflammatory and for the treatment of respiratory disease. Until now, these two properties had not been scientifically demonstrated for Pequi oil in a carrageenan model.

Objective: Our group determined the composition and safe use of Pequi oil from the Savannah of Campo Grande, and the anti-inflammatory and anti-nociceptive activities of this pequi oil were investigated in vivo models.

Materials and Methods: Doses of 300, 700, and 1000 mg/kg of Pequi oil were administered orally (p.o.) to Swiss male mice, and three parameters of inflammation (mechanical hyperalgesia, cold, hyperalgesia, and oedema) were analyzed in a carrageenan model to induce an inflammatory paw state.

Results: The effects of Pequi oil were also carrageenan in pleurisy model, formalin, and acetic acid induced nociception. Oral administration of 1,000 mg/kg orally Pequi oil (p.o.) inhibited (*P<0.05), the migration of total leukocytes, but not alter plasma extravasation, in the pleurisy model when compared to control groups. The paw edema was inhibited with doses of 700 (P <0.05) and 1,000 mg (P<0.001) of pequi oil after 1, 2, and 4 hours after carrageenan. Pequi oil (1,000 mg/kg) also blocked the mechanical hyperalgesy and reduced cold allodynia induced by carrageenan in paw (P <0.05). Pequi oil treatment (1,000 mg/kg) almost blocked (P < 0.001) all parameters of nociception observed in formalin and acid acetic test. This is the first time that the analgesic and anti-inflammatory effects of Pequi oil have been shown.

Keywords:

Anti-edematogenic, anti-hyperalgesic, anti-inflammatory activity, Caryocar brasiliense, antinociceptive, pequi oil.

Affiliation:

Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, University Hospital (HU-UFGD), Federal University of Grande Dourados (UFGD), Dourados, MS, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS, Faculty of Exact Sciences and Technology, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Faculty of Exact Sciences and Technology, Federal University of Grande Dourados, Dourados, Mato Grosso do Sul, Faculty of Health Sciences, Federal University of Grande Dourados (UFGD), Dourados, MS



Read Full-Text article