Submit Manuscript  

Article Details


Mitigation of Radiation-induced Pneumonitis and Lung Fibrosis using Alpha-lipoic Acid and Resveratrol

[ Vol. 19 , Issue. 2 ]

Author(s):

Rasoul Azmoonfar, Peyman Amini, Rasoul Yahyapour, Abolhassan Rezaeyan, Alireza Tavassoli, Elahe Motevaseli, Ehsan Khodamoradi, Dheyauldeen Shabeeb, Ahmed E. Musa and Masoud Najafi*   Pages 149 - 157 ( 9 )

Abstract:


Background: Lung is a radiosensitive organ. Studies have shown that exposure of the lung to acute and high doses of radiation following inhalation of radioactive agents or an accidental radiological event may lead to pneumonitis and fibrosis, which are associated with a risk of death. So far, some agents have been studied for mitigation of pneumonitis and fibrosis following exposure of murine lung tissues to ionizing radiation. In this study, we aimed to detect the possible mitigatory effect of alpha-lipoic acid, resveratrol and their combination on mice pneumonitis and fibrosis markers following irradiation.

Methods: 25 mice were divided into 5 groups: control, radiation; radiation plus alpha-lipoic acid; radiation plus resveratrol; and radiation plus both resveratrol and alpha-lipoic acid. Mice chest regions were irradiated with 18 Gy using a cobalt-60 gamma rays source. Treatments started 24 h after irradiation and continued for two weeks. After 100 days, all mice were sacrificed and their lung tissues removed for histopathological evaluation.

Results: Pathological study showed that exposure to radiation led to severe pneumonitis and moderate fibrosis after 100 days. Both resveratrol and alpha-lipoic acid, as well as their combination could mitigate pneumonitis and fibrosis markers. Although, resveratrol could not mitigate infiltration of most inflammatory cells as well as inflammation and vascular damage, alpha-lipoic acid and its combination were able to mitigate most damaged markers.

Conclusion: Alpha-lipoic acid and its combination with resveratrol were able to mitigate fibrosis and pneumonitis markers in mice lung tissues following lung irradiation. Although resveratrol has a protective effect on some markers, it has a weaker effect on lung injury. In conclusion, our results suggest that the combination of resveratrol and alpha-lipoic acid has a potent mitigatory effect compared to the single forms of these agents.

Keywords:

Alpha-lipoic acid, lung, mitigation, radiation, resveratrol, pneumonitis.

Affiliation:

Department of Radiology and Nuclear Medicine, Kermanshah University of Medical Sciences, Kermanshah, Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Department of Medical Physics, School of Medicine, Fasa University of Medical Sciences, Fasa, Department of Pathology, Fasa University of Medical Sciences, Fasa, Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Department of Radiology and Nuclear Medicine, Kermanshah University of Medical Sciences, Kermanshah, Department of Physiology, College of Medicine, University of Misan, Misan, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences (International Campus), Tehran, Department of Radiology and Nuclear Medicine, Kermanshah University of Medical Sciences, Kermanshah

Graphical Abstract:



Read Full-Text article