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Anti-Inflammatory Effect of Woodfordia Fructicosa Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats

Author(s):

Hem Raj*, Avneet Gupta and Neeraj Upmanyu   Pages 1 - 10 ( 10 )

Abstract:


Background- Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis.

Material and Method- In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund’s adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni’s test was used for statistical analysis.

Result- WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF-α was observed.

Conclusion- These results showed that the WFE exerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticosa afford anti-inflammatory activity by preventing the inflammation in different animal models

Keywords:

Woodfordia fructicosa, Ethanolic extract, Inflammation, Carrageenan, Tumor Necrosis factor, Monosodium Iodo Acetate, Freund’s adjuvant induced, Paw edema, Arthritis.

Affiliation:

Department of Science CMJ University Jorabat, Raibhoi, Meghalaya, Vinayaka college of Pharmacy Kullu(HP), cSchool of Pharmacy and research, People’s University, Bypass road, Bilaspur Bhopal (M.P.)



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