Submit Manuscript  

Article Details


Anti-Inflammatory Effect of Woodfordia Fructicosa Leaves Ethanolic Extract on Adjuvant and Carragenan Treated Rats

[ Vol. 19 , Issue. 2 ]

Author(s):

Hem Raj*, Avneet Gupta and Neeraj Upmanyu   Pages 103 - 112 ( 10 )

Abstract:


Background: Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis.

Methods: In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund’s adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni’s test was used for statistical analysis.

Results: WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed.

Conclusion: These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models.

Keywords:

Arthritis, carrageenan, ethanolic extract, freund’s adjuvant induced, inflammation, monosodium iodo acetate, paw edema, tumor necrosis factor, Woodfordia fructicosa.

Affiliation:

Department of Science, CMJ University Jorabat, Raibhoi, Meghalaya-793101, Vinayaka College of Pharmacy, Kullu (HP), School of Pharmacy and Research, People’s University, Bhopal-462037 (M.P.)



Read Full-Text article