Hem Raj*, Avneet Gupta and Neeraj Upmanyu Pages 103 - 112 ( 10 )
Background: Woodfordia fructicosa is used traditionally for the treatment of inflammation associated with arthritis.Methods: In the present study, the anti-inflammatory activity of W. fructicosa (WFE) leaves ethanolic extract was assessed in Sprague Dawley rats by giving 200 mg/kg dose orally. Inflammation was studied by using carrageenan induced paw edema, Freund’s adjuvant (FA) and monosodium iodo acetate (MIA) induced arthritis as animal models. Serum tumor necrosis factor-alpha (TNF-α) was estimated in blood sample of animals treated with FA. The one way ANOVA followed by Bonferroni’s test was used for statistical analysis. Results: WFE significantly decreased (P<0.05, P<0.001) paw thickness in carrageenan induced paw edema and FA induced arthritis. The significant decrease in knee diameter (P<0.001) in MIA induced arthritis as well as inhibitory effect (P<0.001) on elevated TNF- α was observed. Conclusion: These results showed that the WFEexerted an inhibitory effect on TNF-α and carrageenan paw edema which may justify its traditional use in inflammatory conditions. Thus, the study shows that leaves of W. fruticose afford anti-inflammatory activity by preventing the inflammation in different animal models.
Arthritis, carrageenan, ethanolic extract, freund’s adjuvant induced, inflammation, monosodium iodo acetate, paw edema, tumor necrosis factor, Woodfordia fructicosa.
Department of Science, CMJ University Jorabat, Raibhoi, Meghalaya-793101, Vinayaka College of Pharmacy, Kullu (HP), School of Pharmacy and Research, People’s University, Bhopal-462037 (M.P.)