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Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-Induced IBD Model Rats

Author(s):

Amaldoss M J Newton* and L Prabakaran   Pages 1 - 14 ( 14 )

Abstract:


Objective: Number of various natural polymer-based drug delivery systems targeting the colon is reported for different applications. Most of the research is based on the class of natural polymers such as polysaccharides. This study compares the anti-inflammatory effect of different polysaccharide based tablets on IBD when a drug carrier is targeted to the colon as matrix and coated systems.

Methods: The TNBS induced IBD Wistar rats were used as a model for the study. The microscopic and macroscopic parameters were studied in detail. Almost all the important IBD parameters were reported in this work

Results: The results demonstrated that the polysaccharides are efficient in carrying the drugs to the colon. Reduction in the level of ulcer index (UI), Myeloperoxidase (MPO), Malondialdehyde MDA, confirmed the inhibitory activity on the development of Reactive oxygen species (ROS). The increased level of Tumor necrosis factor (TNF) an expression of colonic Inducible nitric oxide synthase (iNOS) was lowered in treatments as compared to TNBS control.

Conclusion: The different polymer based mesalamine (DPBM) confirmed the efficient anti-inflammatory activity on IBD induced rats. The increased level of glutathione (GSH), superoxide dismutase (SOD) is also confirmed effective anti-inflammatory effect. The significant decrease in the ulcer score and ulcer area was reported. The investigation revealed that chitosan is superior to pectin in IBD treatment likewise polysaccharide-based matrix systems are superior to the coated system.

Keywords:

TNBS, IBD, MPO, MDA, SOD, TNF , chitosan and pectin.

Affiliation:

Jawaharla Nehru Technological University, Hyderabad, Asia Metropolitan University



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