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Antileishmanial Drug Discovery: Synthetic Methods, Chemical Characteristics, and Biological Potential of Quinazolines and its Derivatives

[ Vol. 16 , Issue. 1 ]

Author(s):

Adarsh Sahu*, Deepak Kumar and Ram Kishore Agrawal   Pages 3 - 32 ( 30 )

Abstract:


Background: Leishmaniasis is a complex devastating disease that is widespread across the globe with 400 million people in 90 countries at a risk of acquiring leishmaniasis. It is caused by intracellular parasites belonging to genus Leishmania.

Objective: The therapeutic use of commonly available drugs like Pentostam, Glucantime, Amphotericin B, Paramomycin, and Miltefosine have has been declined due to their low efficacy, drug resistance and high toxicity. Therefore, a continuous effort is needed in order to find out less toxic and more successful drugs in future for the handling of leishmaniasis.

Results: Quinazoline derivatives are reported to have promising antileishmanial activities. A number of quinazoline derivatives were synthesized in the past three decades, by means of various synthetic pathways due to their ease of synthesis and favorable physicochemical properties.

Conclusion: This review focuses on various synthetic procedures, chemical characteristics and antileishmanial activities of various quinazoline derivatives with respect to antileishmanial drug discovery.

Keywords:

Antileishmanial analogues, drug resistance, leishmaniasis, quinazolinone derivatives.

Affiliation:

Department of Pharmaceutical Sciences, Dr. Harisingh Central University, Sagar, MP, P.O. Box: 470002, Department of Pharmaceutical Sciences, Dr. Harisingh Central University, Sagar, MP, Department of Pharmaceutical Sciences, Dr. Harisingh Central University, Sagar, MP

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