Adarsh Sahu*, Deepak Kumar and Ram Kishore Agrawal Pages 3 - 32 ( 30 )
Background: Leishmaniasis is a complex devastating disease that is widespread across the globe with 400 million people in 90 countries at a risk of acquiring leishmaniasis. It is caused by intracellular parasites belonging to genus Leishmania.Objective: The therapeutic use of commonly available drugs like Pentostam, Glucantime, Amphotericin B, Paramomycin, and Miltefosine have has been declined due to their low efficacy, drug resistance and high toxicity. Therefore, a continuous effort is needed in order to find out less toxic and more successful drugs in future for the handling of leishmaniasis. Results: Quinazoline derivatives are reported to have promising antileishmanial activities. A number of quinazoline derivatives were synthesized in the past three decades, by means of various synthetic pathways due to their ease of synthesis and favorable physicochemical properties. Conclusion: This review focuses on various synthetic procedures, chemical characteristics and antileishmanial activities of various quinazoline derivatives with respect to antileishmanial drug discovery.
Antileishmanial analogues, drug resistance, leishmaniasis, quinazolinone derivatives.
Department of Pharmaceutical Sciences, Dr. Harisingh Central University, Sagar, MP, P.O. Box: 470002, Department of Pharmaceutical Sciences, Dr. Harisingh Central University, Sagar, MP, Department of Pharmaceutical Sciences, Dr. Harisingh Central University, Sagar, MP